AGE DEPENDENT MUCOSAL INFLAMMATORY CELL RESPONSE IN COELIAC DISEASE
نویسندگان
چکیده
منابع مشابه
Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients.
BACKGROUND The IL-15/NF-κB axis has an important role in coeliac disease (CD) and may represent a molecular target for immunomodulation. Ascorbate (vitamin C) is known to show inhibitory effects on NF-κB. Therefore, we studied if ascorbate supplementation to gliadin gliadin-stimulated biopsy culture could down-regulate the mucosal immune response to gliadin in CD. METHODS Duodenal biopsy expl...
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serum aLkaline phosphatase was 32 K.A. units/100 ml. These figures were strongly suggestive of neonatal rickets and maternal osteomalacia respectively.X-ray films of the infant's long bones showed evidence of active rickets, most noticeable at the lower femoral epiphyses (fig. 2). Emination of the urine showed generalized amino-aciduria. The infant was treated with 1,000 I.U. of calciferol dail...
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The role of gamma-interferon in the pathogenesis of enteropathies with an immunological basis such as coeliac disease, is unclear. Gamma-interferon immunoreactive lymphocytes were quantified in jejunal biopsies from patients with coeliac disease and from normal controls. In coeliac disease, there was an apparent decrease in the percentage of both intraepithelial (3.5% v 13.5%) and lamina propri...
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In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only one of nine well-treated patients, suggesting that deficiency of this enzyme h...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1990
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199005000-00054